Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

Title: Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
Creator: Watanabe, Hiroshi; Chopra, Nagesh; Laver, Derek; Hwang, Hyun Seok; Davies, Sean S.; Roach, Daniel E.; Duff, Henry J.; Roden, Dan M.; Wilde, Arthur A. M.; Knollmann, Björn C.
Relation: Nature Medicine Vol. 15, Issue 4, p. 380-383
Publisher Link: http://dx.doi.org/10.1038/nm.1942
Publisher: Nature Publishing Group
Resource Type: journal article
Date: 2009
Description: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal inherited arrhythmia syndrome in which drug therapy is often ineffective. We discovered that flecainide prevents arrhythmias in a mouse model of CPVT by inhibiting cardiac ryanodine receptor–mediated Ca²⁺ release and thereby directly targeting the underlying molecular defect. Flecainide completely prevented CPVT in two human subjects who had remained highly symptomatic on conventional drug therapy, indicating that this currently available drug is a promising mechanism-based therapy for CPVT.
Subject: ryanodine receptors; Ca²⁺ release; sarcoplasmic reticulum; mutations
Identifier: uon:7968
Identifier: http://hdl.handle.net/1959.13/916352
Identifier: ISSN:1078-8956
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